30 vegetarian capsules; plain NR formula · UPC 737870234432
Life Extension NAD+ Cell Regenerator 300 mg supplies nicotinamide riboside (NR), a precursor to NAD+. An NR trial found increased blood NAD+, but it did not test whether people lived longer and was not a trial of this finished product. At $1.35 per serving, the cost is hard to justify if your goal is a demonstrated longevity benefit.
This product is intended for adults. If you are pregnant, nursing, or have a medical condition, consult a healthcare professional before use, as advised by the manufacturer's label. The eight-week NR trial assessed short-term safety; it does not establish long-term safety for this finished product.
The plain NAD+ Cell Regenerator label lists 300 mg of NIAGEN nicotinamide riboside chloride per one-vegetarian-capsule serving, with 30 capsules per bottle. The 300 mg amount refers to NR chloride, not NAD+ itself.
This is not the Optimized version or an NMN product. Its Supplement Facts do not list resveratrol, quercetin, or fisetin. The other ingredients are microcrystalline cellulose, vegetable cellulose, silica, and vegetable stearate. Claims about formulas combining NR with other active ingredients should not be transferred to this bottle.
What the NR trial shows
A 2019 randomized, double-blind, placebo-controlled trial studied 140 overweight but otherwise healthy adults over eight weeks, comparing placebo with NR doses of 100, 300, and 1,000 mg. NR increased blood NAD+. The study did not test lifespan or clinical disease prevention, and it was not a trial of Life Extension's finished product.
Participants were predominantly white and middle-aged, and the study limited dietary niacin equivalents. The study also had industry involvement. Its narrow population and short duration limit how broadly the findings can be applied. A higher blood NAD+ measurement does not, by itself, establish that someone will feel more energetic or live longer.
What NIAGEN does not certify
NIAGEN is a licensed ingredient, but its name does not independently certify the potency of the finished capsule. No independent certificate of analysis (COA) for a finished lot was verified for this review. For broader context on evaluating the company without treating its reputation as proof for every product, see our Life Extension brand guide.
This is an optional recurring expense, not a budget basic. NR's blood-marker evidence may interest some buyers, but it does not make a strong value case for someone paying specifically for longer life or a reliable improvement in everyday energy.
Our editorial assessment
Supplement Explained Score
60/100
Five equally weighted criteria. This is an editorial assessment, not customer stars or a measure of medical effectiveness.
Label clarity 5/5
The exact plain 300 mg, 30-count formula identifies NR chloride and its other ingredients; it is not the Optimized multi-ingredient product.
Research relevance 2/5
Short-term human NR studies support a blood NAD+ change, not a demonstrated lifespan or disease-prevention benefit from this finished retail product.
Safety and cautions 3/5
The human evidence has short follow-up and selected populations. Medicines, pregnancy/nursing and existing conditions require professional review rather than a general longevity recommendation.
Testing and quality checks 3/5
NIAGEN names a research-linked ingredient supply, but no independently matched finished-lot potency and contaminant report was verified for this bottle.
Value for money 2/5
The matched $40.50/30 offer costs $1.35 per label serving. Ongoing cost is substantial relative to the uncertain patient-important benefit.
Evaluated from the published Supplement Facts panel, third-party certification records, and clinical references cited below. Unlisted third-party testing lowers the verification score but does not imply contamination.
